Alucinaciones visuales y auditivas secundarias a la interacción farmacológica entre tizanidina y ciprofloxacino / Visual and auditory hallucinations secondary to drug interaction between tizanidine and ciprofloxacin

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Fibromatosis mamaria. Una entidad infiltrativa y deformante benigna de la mama que requiere diagnóstico diferencial con el carcinoma invasor / No disponible

La fibromatosis mamaria es una lesión infrecuente del tejido conectivo que corresponde al 0,2% de los tumores mamarios. Se presenta el caso de una joven de 18 años que consulta por retracción cutánea importante de mama izquierda. El estudio mamográfico y ecográfico reveló la existencia de una densidad focal asimétrica de contorno espiculado de aproximadamente 2 cm en cuadrantes externos de mama izquierda y que tras la biopsia con aguja gruesa (BAG) se diagnosticó de fibromatosis mamaria. Se realizó una exéresis amplia de la lesión, mediante patrón de reducción de Weis, intentando conseguir un resultado estético y quirúrgico adecuado(AU)

Breast fibromatosis is a rare lesion of the connective tissue that corresponds to 0.2% of breast tumors. We report a case of a 18-year-old female, consulting for skin retraction in her left breast. The mammogram showed a focal asymmetric density of irregular edges, of 2 cm in external breast quadrants, and the percutaneous biopsy showed breast fibromatosis. Wide surgical resection was done with Weis reduction pattern, trying to achieve a good esthetic and surgical result(AU)

Identification of a novel HLA-DRB1 allele, DRB1*0108, by sequence-based DRB typing in two siblings.

We report here a novel DRB1 allele identified during sequence-based HLA-DRB typing. This allele was detected during routine HLA typing of a patient and his family prior to bone marrow transplantation. The new allele, DRB1*0108, was found in the patient and in a brother. Molecular cloning and sequencing confirmed that the new DRB1 allele is identical to DRB1*0101 at exon 2 except for a single nucleotide substitution at codon 37 (TauCC-->TauAlphaC), changing the encoded serine to tyrosine. This position of the beta1 domain lies in the floor of the antigen-binding groove and shows the highest polymorphism among DRB1 alleles.

[Serum sialic acid bound to lipoproteins. Its contribution to the diagnosis and follow-up of melanoma]. / Acido siálico sérico unido a lipoproteínas. Su aportación al diagnóstico y seguimiento en melanoma.

Plasma lipid bound sialic acid (LSA) was measurement in 41 patients with malignant melanoma to determine the utility of this biochemical marker in the stating and in monitoring the post-operative follow-up. LSA was determined in 26 cases pre and post-operation, and in 15 cases only post-operation. Multiple determinations was done in 12 cases during two years of post-operative follow-up. Patients with preoperatory determination exhibited LSA levels significantly higher (p 0.0001) than the healthy control group. Relationship between LSA highest levels and tumoral size up 2 cm. in diameter was found (p 0.02). A second determination after 2 months of cases. LSA multiple post-operative controls showed continuing elevation of LSA levels up the normal rates was corresponding with metastasis in 100% of cases.

[Perforating folliculitis]. / Foliculitis perforante.

A case of Perforating Folliculitis is observed, and its clinical and histological aspects are commented upon. Its differential diagnosis and relation to other dermatosis with transepidermal elimination are discussed. Of particular interest, is the extremely chronic aspect of our case.